APC and colorectal carcinoma: In addition to mutations in TP53, other driver mutations in colorectal cancer (CRC) are found in genes of the WNT signaling pathway (e.g., APC and CTNNB1), TGF-β, DCC, SMAD, KRAS, RAF, BRAF, PI3K, PTEN as well as in the DNA mismatch repair genes hMSH3 and hMSH6, beyond other mutations [23].