TP53 and colorectal carcinoma: In CRC cells, the transcription factor AP4 was downregulated by p53, which was indirectly mediated by the tumor-suppressive miR-15a and miR-16-1, targeting the 3′-UTR of AP4 mRNA, inducing mesenchymal-epithelial transition (MET) and inhibiting CRC cell migration and invasion [64].