The p53-induced miR-34 microRNA family mediated repression of c-Kit by p53 via a conserved seed-matching sequence in the cKIT 3′-UTR; ectopic c-Kit expression conferred resistance of CRC cells to 5-FU, whereas ectopic miR-34a sensitized the cells to the drug [62]. The gene discussed is KIT; the disease is colorectal carcinoma.