Importantly, the latency of such NSCLC lesions in K-RasG12D/+;Ahr−/− mice was significantly shorter than in K-RasG12D/+;Ahr+/+ mice, suggesting that Ahr deficiency stresses the tumorigenic potential of K-RasG12D in the lung. The gene discussed is AHR; the disease is non-small cell lung carcinoma.