AHR and neoplasm: To investigate if Ahr had a causal role in the regulation of gene expression programs in K-RasG12D-expressing cells, we performed RNA-seq analyses using two different comparative conditions: (i) K-RasG12D/+;Ahr−/− versus K-RasG12D/+;Ahr+/+ in healthy lung tissue and (ii) K-RasG12D/+;Ahr−/− versus K-RasG12D/+;Ahr+/+ in tumor tissue.