SOCS1 and Miyoshi myopathy: Overall, the more frequently hypermethylated genes in MM are PTGS2 (100%), SFN (100%), CDKN2B (90.2%), CDH1 (88.2%), ESR1 (72.5%), HIC1 (70.5%), CCND2 (62.7%), DCC (45.1%) and TGFβR2 (39.2%), whereas RARβ (16.6%), MGMT (12.5%), AIM1 (12.5%), CDKN2A (8.3%), SOCS-1 (8.3%), CCNA1 (8.3%) and THBS1 (4.1%) are rarely found to be hypermethylated [58].