The activating mark H3K4me3 and the repressing polycomb chromatin mark H3K27me3 are enriched in MM [93], and especially, H3K27me3 is associated with the under-expression of PRC2 target genes (CXCL12, GATA2, CDH6, CIITA and ICSBP/IRF8) in most cases of MM, thereby influencing cell growth [94]. This evidence concerns the gene IRF8 and Miyoshi myopathy.