The interplay of MM cells with bone homeostasis is regulated via many factors, including osteoclast stimulating factors (MIP-1α, RANKL, VEGF, TNF-α, IL-1β, HGF and IL-6) and osteoblast inhibitory factors (IL-3, IL-7 and the Wnt pathway inhibitor DKK1) [13,21]. This evidence concerns the gene VEGFA and Miyoshi myopathy.