Adamik and colleagues could show that the binding of GFI1 to the Runx2 promoter in BMSCs initiates the recruitment of HDAC1 and EZH2, thereby enhancing the level of the Runx2 repressive chromatin mark H3K27me3, ultimately preventing osteoblast differentiation and promoting MM bone disease. This evidence concerns the gene EZH2 and Miyoshi myopathy.