RUNX2 and Miyoshi myopathy: Walker and colleagues showed that, during the progression from MGUS to MM, hypermethylation occurs in many promoters of genes involved in gene regulation (ACVR1, ARID3A, BRCA2, C19orf33, CALCA, CBX4, FOXD2, GATA4, HIPK3, HOXB8, HOXD11, ID4, IRF7, LDB1, NCOR2, ONECUT2, RAB37, RUNX2, ZIC1, ZNF385 and ZNF560) or in regulators of the cell cycle (AIF1, BCL2, CDKN2B, GAS2L1, ID4, MPHOSPH9 and PKMYT1) [36].