ISG15 and Miyoshi myopathy: The inhibition of EZH2 and G9 reduces methylation at H3K27/H3K9, which, in turn, upregulates genes associated with the interferon and immune responses (such as OAS3, IFI6, IRF9, IFIT1 and ISG15) and suppresses genes important for MM survival, such as IRF4, MYC, KLF2 and PRDM1 [85].