Of these 13 RNA-Seq genetic subtypes, five are especially high-risk: (1) BCR-ABL1, (2) KMT2A-r, (3) MEF2D, (4) HLF-r, and (5) CRLF2/BCR-ABL1-like ALL. The gene discussed is CRLF2; the disease is acute lymphoblastic leukemia.