Subtle but important differences exist in the profile of genetic subtypes between these two cohorts, for example in the proportions of DUX4 (4% in St Jude vs. 12% in Ma-Spore), BCR-ABL-like (12% in St Jude vs. 2% in Ma-Spore), PAX5alt (4% in St Jude vs. 9% in Ma-Spore), and T-ALL (15% in St Jude vs. 9% in Ma-Spore). The gene discussed is ABL1; the disease is acute lymphoblastic leukemia.