Src homology 2 domain-containing phosphotyrosine phosphatase 2 (SHP2) is a proven oncogene for TC, and phase-changeable polylactic-co-glycolid acid (PLGA) polymeric nanoparticles decorated with SHP2 antibody were able to strongly label tumor tissue when applied to tumor-bearing mice and irradiated with LIFUS [59]. Here, PTPN11 is linked to neoplasm.