In the presence of tumor cells, cell and vessel densities and the percentages of cells staining positive for CAIX, LDHA and Ki67 exceeded the numbers that were detected in specimens without tumor cells (p < 0.001, p = 0.006, p = 0.003, p = 0.002, and p < 0.001, respectively). The gene discussed is MKI67; the disease is neoplasm.