ERBB2 and breast cancer: Analysis of transcriptomic data combined from 35 independent studies (www.kmplot.com (accessed on 1 April 2019) [19]) showed that the TSP1 mRNA level, encoded by the THBS1 gene, was significantly associated with a reduced survival in breast cancers, including ER-/PR-/HER2-TNBC (Figure 1A).