ABCB1 and Familial prostate cancer: Nonetheless, several studies reported a temporal correlation between the acquisition of docetaxel resistance and the upregulation of the Multidrug Resistance Protein 1 (MDR1) or ATP-Binding Cassette Sub-Family B Member 1 transporter (encoded by the ABCB1 gene locus) in ovarian, breast, and prostate cancer [11,12,13].