Firstly, PCWBR2 directly interacts with α2/β integrin, a receptor generally overexpressed in human CRC tumors and cell lines, which might explain why P. anaerobius preferentially colonizes the CRC tumors [156]; and second, P. anaerobius activated the α2/β1-PI3K–Akt–NF-κB signaling cascade to trigger the inflammation in ApcMin/+ mice. The gene discussed is AKT1; the disease is colorectal carcinoma.