Taking into account the reports on PD-L1 expression on tumor cells associated with immune-escape and T-cell non-responsiveness, findings on PD-1 expression on CTLs, as well as promising preliminary results with PD-1 blockade therapy in T-DLBCL, the results on immune checkpoint molecule expression in T-DLBCL can be seen somewhat paradoxical [28]. This evidence concerns the gene CD274 and diffuse large B-cell lymphoma.