Frequent copy number alterations and translocations of 9p24.1 resulting in increased expression of PD-L1/L2 proteins as well as loss of HLA genes are among the characteristic genetic features of T-DLBCL and PCNSL, highlighting the significant role of the TME and immune-escape in these diseases [8,9,95,99,100]. This evidence concerns the gene CD274 and diffuse large B-cell lymphoma.