In T-DLBCL, rearrangements of CD274 and PDCD1LG2 (coding programmed cell death ligands 1 and 2, PD-L1 and PD-L2, respectively) and BCL6 have been associated with increased risk of CNS relapse, and mutations of TBL1XR1 and overexpression of p53 with inferior outcome [96,97,98]. The gene discussed is CD274; the disease is diffuse large B-cell lymphoma.