The pro-tumor role of PLEXIND1 has been reported to be mediated by p61-Sema 3E/PLEXIND1 in colon cancer [7] and Sema 3E/PLEXIND1 signaling in ovarian endometrioid cancer [39]; in prostate cancer PLEXIND1 has been shown to act as a transcriptional target stimulated by the Notch signaling that helped in Slug- mediated E-cadherin downregulation [3]. This evidence concerns the gene CDH1 and prostate carcinoma.