To investigate the role of GBP5 in OSCC cancer stemness, gene expression levels of several cancer stemness markers such as aldehyde dehydrogenase 1 Family Member A1 (ALDH1A1), ALDH1A2, CD44, CD166, and ABCG2 were analyzed in GBP5-knockdown OSCC cells. The gene discussed is ALDH1A1; the disease is cancer.