Several studies have investigated the role of anti-pituitary and anti-hypothalamus antibodies in LYH [20,21,31,32,33,34]; however, studies on the detection of these antibodies in irAEs, occurring in cancer patients treated with ICIs and especially in those treated with PD-1 and PD-L1 inhibitors, are rare and have only addressed the occurrence of APA but not of AHA. This evidence concerns the gene PDCD1 and cancer.