We also evaluated the presence of autoimmunity in relation to the time from the start of immunotherapy, and we observed that 24 patients had been on treatment for less than 6 months and 30 for at least 6 months; 9 of 24 patients (37.5%) in treatment for less than 6 months were APA- or AHA-positive, while 17 of 30 patients (56%) who had been on treatment for at least 6 months were APA-or AHA-positive (p = 0.26). This evidence concerns the gene ENPEP and Autoimmunity.