CD4 and neoplasm: The expression of CD3+ PD-1+TIM-3+ (median 5.91 (range 0.01–10.39) vs. 0.27 (range 0–0.63), p < 0.05), and CD3+CD4+ PD-1+TIM-3+ (median 3.41 (range 0–10.3) vs. 0.33 (range 0–1.6), p < 0.05), was significantly higher in the tumour than in the lymph node (Figure 5).