In addition, PTE can inhibit tumor cells through modulation of Akt, mitogen-activated protein, metastasis-associated protein 1, oxidative stress, endoplasmic reticulum stress, mitochondrially derived apoptosis, autophagy-dependent manner autophagy, cell cycle arrest and non-apoptotic pathways [28,30,31,32,58,59,60,61,62]. The gene discussed is AKT1; the disease is neoplasm.