BCR-ABL induced SOCS2 upregulation in CML cell lines, and SOCS2 expression was suppressed in vivo upon BCR-ABL tyrosine kinase inhibition [18], suggesting a role of BCR-ABL signaling in the regulation of SOCS2 expression. The gene discussed is ABL1; the disease is chronic myelogenous leukemia, BCR-ABL1 positive.