IL15 and neoplasm: The CAM1615HER2 TriKE induced dynamic and robust killing of the tumor, noted by changing of the spheroid color from green (live SKOV3 cells) to black (dead SKOV3 cells), within 48 h, while the IL-15 group induced less killing over the three-day period but more than the no treatment and CAM16 controls (Figure 4A).