The authors go on to demonstrate that intracerebroventricular injection of INSL3 alone is capable of inducing appetite suppression in mice, serum INSL3 levels were significantly increased in patients with pancreatic cancer cachexia and serum INSL3 levels were negatively correlated to calorie intake in PDAC patients [102]. The gene discussed is INSL3; the disease is pancreatic neoplasm.