In addition to cytokines being received and amplified in the CNS during cachexia, a recent report from our lab demonstrates a clear role for myeloid cell invasion in the CNS in driving pancreatic cancer cachexia symptoms, including anorexia and lean mass catabolism, that is predominantly driven by the CCR2–CCL2 axis [7]. The gene discussed is CCR2; the disease is pancreatic neoplasm.