ANG-2 expression is upregulated in tumor-associated vessel endothelium, and high serum ANG-2 concentrations are associated with increased malignancy in several types of cancer, such as hepatocellular cancer, lung cancer, glioblastoma, and cutaneous melanoma [30,31,32,33,34,35,36]. Here, ANGPT2 is linked to hepatocellular carcinoma.