AKT1 and neoplasm: Additionally, we used a multivariate visualization approach to identify p-AKT, AR-V and p-GSK3β as factors associated with apalutamide treatment (Figure 2D) and used Pearson correlation to identify positive correlations between tumor burden, AR-V, p-AKTpS473, P-S6, p-PRAs40 and p-STATpY705 in the apalutamide-treated tumors and tumor burden, AR-HMW250 and p-STATpY705 in surgically castrated mice (Supplementary Figure S2D).