PTEN and prostate neoplasm: We next examined the histopathological changes associated with apalutamide therapy in prostate tumors from Pten-KO mice in Figure 1A. Histological changes associated with androgen deprivation, such as atrophy, decrease in the size of malignant glands, loss of luminal space and increased stroma, were observed in prostate tumors from mice treated with apalutamide.