Considering that HGSC patients with a higher expression of (z-score > 1) RPL23 mRNA exhibited a worse prognosis than other patients in our study and that both ccRCC and HGSC are characterized by high genomic instability, the altered USP19 and RPL23 expressions might be related to genomic instability in cancers. Here, USP19 is linked to nonpapillary renal cell carcinoma.