IPA analyses of the 28 proteins indicated alterations in integrin signaling and actin cytoskeleton signaling among top enriched pathways whereas top predicted molecular functions were related to cellular movement, and cell-to-cell signaling and interaction (Appendix A Table A4), supporting YAP1-associated signatures of cytoskeletal re-arrangement and EMT as prominent features manifest in blood of SCLC cases. The gene discussed is YAP1; the disease is small cell lung carcinoma.