This is further confirmed by the observation that modulating ELOVL5 expression in C4-2 by either CRISPR-Cas9 knocking out or overexpressing led to the opposite change of NSE and NKX3.1 expression, two markers representing neuroendocrine PCa and luminal PCa cells, respectively (Figure 3C). Here, ENO2 is linked to posterior cortical atrophy.