Oncogenic ATK signaling can be activated by the changes of cell membrane contents, such as increased lipid rafts, and further contributes to hyperactivation of mTORC1 and mTORC2 [8], and as a consequence, the activation of the AKT-mTOR pathway can contribute to the enzalutamide resistance of prostate cancer [13]. Here, AKT1 is linked to Familial prostate cancer.