As shown in Figure 2A, except for O-acetylcarnitine and butyrylcarnitine, most fatty acylcarnitine were significantly reduced in their levels in the PC3 and LNCaP/AR-shp53shRB cells compared to LNCaP and LNCaP/AR, respectively (Figure 2A,B), indicating that FAO is downregulated in NE-like PCa cells. This evidence concerns the gene AR and posterior cortical atrophy.