AR and posterior cortical atrophy: Knockdown of ELOVL5 by siRNA in two NE-like PCa cell lines, LNCaP/AR-shp53/shRB and PC3, led to the downregulation of neuroendocrine markers SYP (Figure 3A) whereas overexpression of ELOVL5 in LNCaP/AR and CWRR1 cells resulted in the upregulation of SYP (Figure 3B), suggesting that ELOVL5 may be involved in NE development.