Since we already demonstrated that EGFR and Bcl-xL are direct targets of miR-491-5p in IGROV1-R10 ovarian cancer cells, and that the most striking phenotype upon miR-491-5p transfection is the induction of cell death, we did expect to identify pathways related to cell death and/or MAPK. This evidence concerns the gene EGFR and ovarian carcinoma.