PIK3CA and neoplasm: The presence of PIK3CA alterations significantly correlated with high pathological grade (p < 0.001) and large tumor size (p < 0.05), as well as with decreased disease-free survival (DFS) and OS (p < 0.05 in both instances) [48], in agreement with previous studies describing the role of PIK3CA alterations in cervical tumorigenesis [52].