PIK3CA and neoplasm: Several deregulated miRNAs have been proposed as putative therapeutic targets; in this regard, miR-486-5p, namely, an activator of the PI3K/Akt pathway via PTEN, was found by Li and coworkers to act not only as a reliable CC diagnostic biomarker (AUC = 0.90) in agreement with previous findings [73,82,84] but also as a promising target, as emerged from pre-clinical experiments in which the specific inhibition of miR-486-5p in human CC HeLa cells reduced proliferation, migration, and colony formation potential while impairing tumor formation in mice [82].