The multivariable analysis consisted of significant factors in the univariable analysis (p < 0.1), and revealed that hypertension (OR: 3.0, range, 0.31–6.84, p = 0.05) and a hemoglobin value of more than 12 mg/dL (OR: 2.7, range, 1.07–6.8, p = 0.035) significantly increased a good PSA response rate. The gene discussed is KLK3; the disease is Hypertension.