MeCP2 functions as a transcriptional co-activator of SMAD3 in mediating the SMAD-dependent transcriptional activation of Furin, which is a member of the family of subtilisin/kexin-like proprotein convertases that has been shown to promote migration and invasion of tumor cells, forming a positive feedback axis that promotes EMT in PC cells [71]. The gene discussed is SMAD3; the disease is neoplasm.