Consistent with contemporary knowledge that molecular interactions induced or facilitated by proline-rich motifs characterize many aspects of the immune response, and that these proline-rich factors mediate cell–cell communication, signal transduction, and antigen recognition [31], we also demonstrated that the GSE1 and TACSTD2 signal interplay affects the clinical and immune status and is indicative of the therapy responses and clinical outcomes in patients with PCa (Figure 4 and Figure 5). The gene discussed is TACSTD2; the disease is posterior cortical atrophy.