As mentioned in the introduction, the authors performed whole-exome sequencing and found that EZB subtype mainly harbored EZH2 mutations and BCL2 translocations, mapping to the previously described C3 and BCL2 clusters, and exhibits frequent inactivation of TNFRSF14, with inferior outcome to other GCB patients within GCB DLBCL. This evidence concerns the gene EZH2 and diffuse large B-cell lymphoma.