Based on the foregoing, in the present study, we investigated the anticancer effects of MIA-602 and MIA-690 in GH/PRL-secreting GH3-GHRHR cell line transfected with human GHRH-R, and in ACTH-producing AtT20/D16v-F2 pituitary tumor cells. The gene discussed is GH1; the disease is pituitary tumor.