Furthermore, the role of GHRH antagonists of JV series in blocking GHRH actions was described in the same in vitro model of somatotroph adenoma used in this study, i.e., rat pituitary GH3 cells that were induced to express a functional human GHRH-R [23,33,43]. The gene discussed is GHRH; the disease is growth hormone secreting pituitary adenoma 1.