Therefore, along with the established potent antitumor role of these compounds in different tumors, GHRH antagonists of MIA series could represent a novel treatment option for PAs because of their ability to reduce cell viability and increase apoptosis in GH-PAs and ACTH-PAs, as well as for their inhibitory effects on GH secretion and cAMP signaling in somatotroph cell lines. The gene discussed is GH1; the disease is gonorrhea.