The inhibition of apoptosis and the advancement of tumour growth may be due to the over-activation of the NF-kB system generated by the triggering of PI3K/Akt [140,141]; as result, NF-kB is able to accelerate the cell cycle process in tumour cells, contributing to the development of multidrug-resistance [142,143]. This evidence concerns the gene NFKB1 and neoplasm.