Considering that DUSP6 affects ERK signaling through dephosphorylation, or nuclear translocation inhibition [101], and that ERK signaling blockade suppresses proliferation and invasion of cancer cells, the epigenetic modification in transcriptional regulation of DUSP6 gene promoted by haloperidol in PC cells appears to contribute to its antiproliferative activity. Here, DUSP6 is linked to pachyonychia congenita.