TXNRD1 and cancer: In particular, a first study showed that auranofin affects the viability of multiple PC cell lines with IC50 values all below 5 μmol/L, possibly through the inhibition of one of the major redox systems, namely thioredoxin reductase 1 (TrxR1), which in turn leads to decreased antioxidant activity within cancer cells, followed by apoptosis induction [20].