Accordingly, subsets were defined as follows: a CD209+CD11c− M2 subset, which was the only group detected in normal skin (depicted in red in control skin dot-plot), CD209−CD11c+ M1 subset, which appeared as a new population in both metastases and primary melanomas, and CD209+CD11c+ (mixed population) (Figure 1A,B). The gene discussed is ITGAX; the disease is melanoma.