Similarly, previous results from MBTA therapy of murine pancreatic adenocarcinoma (Panc02) have shown that CD4+ T cells are important for the complete eradication of tumor growth and resistance to its recurrence in CD8−/− knockout mice, suggesting that CD4+ T cells might play diverse anti-tumor roles in different types of murine tumor models [37]. This evidence concerns the gene CD8A and pancreatic adenocarcinoma.