Carcinomas arising from both Iqgap1+/+K14-E6E7 and Iqgap1−/−K14-E6E7 mice showed similar expression levels and patterns of pERK and pS6, two biomarkers associated with HPV-positive cancer [111,112,113,114], indicating that the loss of IQGAP1 did not reduce the levels of either the RAS-MARK or the PI3K signaling in this model. This evidence concerns the gene PIK3CA and cancer.