At 6 months post-infection, MmuPV1-infected Iqgap1+/+ mice developed more severe tumor phenotypes, including tumor incidence, tumor multiplicity and disease severity, that were significantly higher than in MmuPV1-infected Iqgap1−/− mice, which had tumor phenotypes very similar to those of mock-infected mice [103]. This evidence concerns the gene IQGAP1 and neoplasm.