In a recent study, the Ec1-LoPE fusion protein demonstrated significant inhibition of tumor growth in a BT-474 breast cancer model, and its combination with HER2-targeting liposomes coated with DARPin 9_29 and loaded with the ribonuclease Barnase led to the elimination of both primary tumors and metastases [54]. The gene discussed is ERBB2; the disease is neoplasm.