Our work is supported by previous observations with detacibine (5-aza-2′-deoxycytidine), another DNMT1 inhibitor, which has shown a similar apoptosis-inducing ability via the TRAIL pathway in acute myeloid leukemia and in HRASG12V-transformed cells [32,33]. The gene discussed is TNFSF10; the disease is acute myeloid leukemia.