Further, as nuclear PKM2 is required for EGF-involved EMT-mediated cell migration in HCCs, oral squamous carcinomas, and colon cancers [56,60,61], further work is also needed to fully define the mechanisms by which nuclear PKM2 promotes cell motility under EGFR activation in NSCLC, potentially through mediating the transcriptional activation of migration-dependent genes (Figure 8). Here, EGF is linked to colonic neoplasm.