Finally, due to the fundamental organization of CENP-A foci conserved in every tissue examined, CENP-A pattern could be considered for predicting response to CCRT in other clinical situations, such as anal carcinomas, cervix carcinomas and locally advanced non-small cell lung or esophagal carcinomas that are potentially curable by CCRT. Here, CENPA is linked to carcinoma of esophagus.