Of note, a wide range of broad-spectrum antibiotics has been frequently prescribed for ICU patients, including piperacillin-tazobactam, meropenem, amoxicillin, beta lactam-beta lactamase inhibitor, imipenem, moxifloxacin, aminoglycosides, trimethoprim-sulfonamide, lincosamides, tigecycline, and daptomycin, highlighting potential further development of current or future AMR as most of them have been prescribed empirically or as prophylaxis to prevent secondary bacterial infection [62]. This evidence concerns the gene LACTB and bacterial infectious disease.