IL1B and Sepsis: IgM and IgA enriched immunoglobulin G use in patients undergoing hematopoietic stem cell transplantation (HSCT) produced a significant decrease in infection-associated transplant related mortality rate [29], decreased the key inflammasome IL-1β molecule in an Escherichia coli-model of pig’s sepsis [30] and reduced the hepatic toxicity in patients who underwent bone marrow transplant [31].