TP53 and Infertility: Meanwhile, studies have shown that the inhibition of Hsp27 phosphorylation retarded P53 induction and resulted in cell apoptosis; the increase in HSPs and decrease in P53 could protect and restore the damaged reproductive system in the testis, so we can conclude that the upregulation of P53 would lead to cell apoptosis, abnormal meiosis, and further infertility [15,16].