PRNP and scrapie: Therefore, breeding for resistance to TSE programs should be individualized, and 110P, 146S, and 146D alleles should be considered on an evidential basis, following (i) an appropriate epizootiological investigation of the disease, (ii) identification of candidate PrP gene polymorphic alleles that may confer susceptibility or resistance to goat scrapie, (iii) genetic profiling of the existed population, and (iv) assessment of potential impacts on the productivity, health, and welfare status of animals.