PRNP and scrapie: Control strategies which have been utilized over the years for small ruminants include: (i) Complete herd depopulation, (ii) depopulation of genetically related animals (maternal transmission), (iii) depopulation of animals at risk, (iv) culling of affected animals, (v) cleaning and disinfection of premises and equipment, (vi) sufficient period until animals will be restocked in the premises, and (vii) selective breeding schemes based on the PrP gene polymorphisms (only for classical scrapie) [8,9].