In line with this, T lymphocytes produce tumor necrosis factor alpha (TNF-α), which can induce the apoptosis of macrophages, decreasing their accumulation in the tumor [49] and explaining the high level of macrophage turnover that has been confirmed in T-cell lymphomas in contrast to B-cell lymphomas, although the total number of TAM was higher in the latter. The gene discussed is TNF; the disease is neoplasm.