Therefore, this present study compares the serum concentrations of proinflammatory (IL-12, GM-CSF and IFN-γ) and anti-inflammatory (IL-10, IL-4) cytokines, proinflammatory to anti-inflammatory cytokine ratios, oxidant (malondialdehyde) and antioxidant enzymes (superoxide dismutase; glutathione peroxidase) from symptomatic and asymptomatic cattle with blood parasite infections. This evidence concerns the gene IL4 and parasitic infectious disease.