The early post-operative course was atypical of uncomplicated appendicitis, with persisting abdominal pain, inappetence and weakness, low urinary output and high levels of procalcitonin (9.4 μg/L; (<0.1 μg/L)), ferritin (861 μg/L; (14–124 μg/L)), NT-proBNP (n-terminal pro brain natriuretic peptide, 15,844 ng/L; (<125 ng/L)), D-dimers (3.98 μg/mL; (0.19–0.5 μg/mL)) and troponin (128 ng/L; (<14 ng/L)) with normal creatine kinase on extended laboratory work-up. This evidence concerns the gene NPPB and appendicitis.