Genome-wide association studies (GWAS) investigating 522 JIA patients, 192 of which experienced uveitis [60], showed that the presence of a serine amino acid residue at position 11 of the YST motif, comprised of tyrosine (Y), serine (S), and threonine (T), of the HLA–DRβ1 peptide-binding groove associates with increased risk for the development of uveitis in girls. The gene discussed is HLA-DRB1; the disease is juvenile idiopathic arthritis.