In the current study, despite 6 out of 10 patients with T2DM onset presenting polyuria and polydipsia, none developed AKI, probably as, in the setting of T2DM, the polyuria is lesser in degree compared with T1DM setting, where the lack of insulin and the osmotic diuresis could be massive with subsequent increased risk of hypovolemia. This evidence concerns the gene INS and type 2 diabetes mellitus.