Those including REG1A, KLK8, KLK12 and MAGEA are up regulated in IVE group, among which REG1A and KLK8 predict poor prognosis in CRC [33, 34], while silence of KLK12 and MAGEA can inhibit CRC growth and promote cell death [35, 36]. This evidence concerns the gene KLK12 and colorectal carcinoma.