Indeed, the lethality of Ripk1D325A/D325ACasp8−/− embryos can be rescued by Mlkl−/− to adulthood, similar to Casp8−/− embryos (Fig 2C), and the resulting Ripk1D325A/D325ACasp8−/−Mlkl−/− mice exhibited similar lpr phenotypes (lymphadenopathy and splenomegaly) to those of Casp8−/−Mlkl−/− mice [27,40] (S3A Fig). Here, MLKL is linked to Splenomegaly.